Reduction of Seizure Occurrence from Exposure to Auditory Stimulation in Individuals with Neurological Handicaps: A Randomized Controlled Trial
Identifieur interne : 000396 ( Main/Exploration ); précédent : 000395; suivant : 000397Reduction of Seizure Occurrence from Exposure to Auditory Stimulation in Individuals with Neurological Handicaps: A Randomized Controlled Trial
Auteurs : Mark Bodner [États-Unis] ; Robert P. Turner [États-Unis] ; John Schwacke [États-Unis] ; Christopher Bowers [États-Unis] ; Caroline Norment [États-Unis]Source :
- PLoS ONE ; 2012.
Abstract
The purpose of this work was to determine in a clinical trial the efficacy of reducing or preventing seizures in patients with neurological handicaps through sustained cortical activation evoked by passive exposure to a specific auditory stimulus (particular music). The specific type of stimulation had been determined in previous studies to evoke anti-epileptiform/anti-seizure brain activity.
The study was conducted at the Thad E. Saleeby Center in Harstville, South Carolina, which is a permanent residence for individuals with heterogeneous neurological impairments, many with epilepsy. We investigated the ability to reduce or prevent seizures in subjects through cortical stimulation from sustained passive nightly exposure to a specific auditory stimulus (music) in a three-year randomized controlled study. In year 1, baseline seizure rates were established. In year 2, subjects were randomly assigned to treatment and control groups. Treatment group subjects were exposed during sleeping hours to specific music at regular intervals. Control subjects received no music exposure and were maintained on regular anti-seizure medication. In year 3, music treatment was terminated and seizure rates followed. We found a significant treatment effect (p = 0.024) during the treatment phase persisting through the follow-up phase (p = 0.002). Subjects exposed to treatment exhibited a significant 24% decrease in seizures during the treatment phase, and a 33% decrease persisting through the follow-up phase. Twenty-four percent of treatment subjects exhibited a complete absence of seizures during treatment.
Exposure to specific auditory stimuli (i.e. music) can significantly reduce seizures in subjects with a range of epilepsy and seizure types, in some cases achieving a complete cessation of seizures. These results are consistent with previous work showing reductions in epileptiform activity from particular music exposure and offers potential for achieving a non-invasive, non-pharmacologic treatment of epilepsy.
Clinicaltrials.gov
Url:
DOI: 10.1371/journal.pone.0045303
PubMed: 23071510
PubMed Central: 3469625
Affiliations:
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Turner</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Neurosciences, Pediatrics, Epidemiology & Biostatistics, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, Pediatrics, Epidemiology & Biostatistics, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Schwacke, John" sort="Schwacke, John" uniqKey="Schwacke J" first="John" last="Schwacke">John Schwacke</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Epidemiology and Biostatistics, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Bowers, Christopher" sort="Bowers, Christopher" uniqKey="Bowers C" first="Christopher" last="Bowers">Christopher Bowers</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Norment, Caroline" sort="Norment, Caroline" uniqKey="Norment C" first="Caroline" last="Norment">Caroline Norment</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="e-ISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The purpose of this work was to determine in a clinical trial the efficacy of reducing or preventing seizures in patients with neurological handicaps through sustained cortical activation evoked by passive exposure to a specific auditory stimulus (particular music). The specific type of stimulation had been determined in previous studies to evoke anti-epileptiform/anti-seizure brain activity.</p></sec><sec><title>Methods</title><p>The study was conducted at the Thad E. Saleeby Center in Harstville, South Carolina, which is a permanent residence for individuals with heterogeneous neurological impairments, many with epilepsy. We investigated the ability to reduce or prevent seizures in subjects through cortical stimulation from sustained passive nightly exposure to a specific auditory stimulus (music) in a three-year randomized controlled study. In year 1, baseline seizure rates were established. In year 2, subjects were randomly assigned to treatment and control groups. Treatment group subjects were exposed during sleeping hours to specific music at regular intervals. Control subjects received no music exposure and were maintained on regular anti-seizure medication. In year 3, music treatment was terminated and seizure rates followed. We found a significant treatment effect (p = 0.024) during the treatment phase persisting through the follow-up phase (p = 0.002). Subjects exposed to treatment exhibited a significant 24% decrease in seizures during the treatment phase, and a 33% decrease persisting through the follow-up phase. Twenty-four percent of treatment subjects exhibited a complete absence of seizures during treatment.</p></sec><sec><title>Conclusion/Significance</title><p>Exposure to specific auditory stimuli (i.e. music) can significantly reduce seizures in subjects with a range of epilepsy and seizure types, in some cases achieving a complete cessation of seizures. These results are consistent with previous work showing reductions in epileptiform activity from particular music exposure and offers potential for achieving a non-invasive, non-pharmacologic treatment of epilepsy.</p></sec><sec><title>Trial Registration</title><p>Clinicaltrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT01459692?term=NCT01459692">NCT01459692</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schwartzkroin, Pa" uniqKey="Schwartzkroin P">PA Schwartzkroin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Timofeev, I" uniqKey="Timofeev I">I Timofeev</name></author><author><name sortKey="Bashenov, M" uniqKey="Bashenov M">M Bashenov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccormick, Da" uniqKey="Mccormick D">DA McCormick</name></author><author><name sortKey="Contreras, D" 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Hughes</name></author><author><name sortKey="Fino, Jj" uniqKey="Fino J">JJ Fino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Jr" uniqKey="Hughes J">JR Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenkins, Js" uniqKey="Jenkins J">JS Jenkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rauscher, Fh" uniqKey="Rauscher F">FH Rauscher</name></author><author><name sortKey="Shaw, Gl" uniqKey="Shaw G">GL Shaw</name></author><author><name sortKey="Ky, Kn" uniqKey="Ky K">KN Ky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hetland, L" uniqKey="Hetland L">L Hetland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaw, Gl" uniqKey="Shaw G">GL Shaw</name></author><author><name sortKey="Bodner, M" uniqKey="Bodner M">M Bodner</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Mp" uniqKey="Jacobs M">MP Jacobs</name></author><author><name sortKey="Leblanc, Gg" uniqKey="Leblanc G">GG Leblanc</name></author><author><name sortKey="Brooks Kayal, A" uniqKey="Brooks Kayal A">A Brooks-Kayal</name></author><author><name sortKey="Jensen, Fe" uniqKey="Jensen F">FE Jensen</name></author><author><name sortKey="Lowenstein, Dh" uniqKey="Lowenstein D">DH Lowenstein</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Sud</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name></region><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><name sortKey="Bowers, Christopher" sort="Bowers, Christopher" uniqKey="Bowers C" first="Christopher" last="Bowers">Christopher Bowers</name><name sortKey="Norment, Caroline" sort="Norment, Caroline" uniqKey="Norment C" first="Caroline" last="Norment">Caroline Norment</name><name sortKey="Schwacke, John" sort="Schwacke, John" uniqKey="Schwacke J" first="John" last="Schwacke">John Schwacke</name><name sortKey="Turner, Robert P" sort="Turner, Robert P" uniqKey="Turner R" first="Robert P." last="Turner">Robert P. 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